Abstract
Tumor necrosis factor alpha (TNF alpha) stimulates production of granulocyte colony-stimulating factor (G-CSF) protein and mRNA in fibroblast cells. In contrast, TNF beta is at least 1,000-fold less potent than TNF alpha in increasing levels of G-CSF and GM-CSF activity and mRNA. The fibroblasts produce G-CSF and GM-CSF mRNA in a coordinate fashion after exposure to TNF. The ability of TNF alpha to stimulate production of CSF in fibroblasts may be pivotal to regulation of hematopoiesis.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Cells, Cultured
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Colony-Stimulating Factors / biosynthesis*
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Fibroblasts / metabolism
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Glycoproteins / pharmacology*
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Granulocyte Colony-Stimulating Factor
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Humans
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Interleukin-1 / physiology
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Interleukin-3 / biosynthesis
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RNA, Messenger / biosynthesis
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Recombinant Proteins / pharmacology*
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Tumor Necrosis Factor-alpha
Substances
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Colony-Stimulating Factors
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Glycoproteins
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Interleukin-1
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Interleukin-3
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RNA, Messenger
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Recombinant Proteins
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Tumor Necrosis Factor-alpha
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Granulocyte Colony-Stimulating Factor