Implication of HLA-G 3' untranslated region polymorphisms in human papillomavirus infection

D Bortolotti; V Gentili; A Rotola; D Di Luca; R Rizzo

doi:10.1111/tan.12281

Implication of HLA-G 3' untranslated region polymorphisms in human papillomavirus infection

Tissue Antigens. 2014 Feb;83(2):113-8. doi: 10.1111/tan.12281. Epub 2014 Jan 7.

Authors

D Bortolotti¹, V Gentili, A Rotola, D Di Luca, R Rizzo

Affiliation

¹ Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy.

PMID: 24397524
DOI: 10.1111/tan.12281

Abstract

Human papillomavirus (HPV) infection is involved in cervical lesion development. It interferes with host immune response and modifies the expression of human leukocyte antigen-G (HLA-G), a nonclassical HLA-I antigen with immune-inhibitory functions. We analyzed the frequencies of two HLA-G 3' untranslated region polymorphisms (14 bp ins/del, +3142C>G), involved in HLA-G modulation, in 33 condyloma acuminatum, 14 low grade squamous intraepithelial lesion and 100 invasive cervical cancer (ICC) HPV infected patients. We showed the involvement of HLA-G polymorphisms in HPV infection and lesion development, and suggested that 14 bp del allele promotes high-risk HPV infection, with del/C haplotype associated with ICC development. On the basis of these evidences, HLA-G polymorphisms could represent a risk factor in HPV positive subjects.

Keywords: human leukocyte antigen-G; human papillomavirus; invasive cervical cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

3' Untranslated Regions*
Alleles
Condylomata Acuminata / genetics*
Condylomata Acuminata / immunology
Condylomata Acuminata / pathology
Condylomata Acuminata / virology
Female
Genetic Predisposition to Disease
HLA-G Antigens / genetics*
HLA-G Antigens / immunology
Haplotypes
Humans
Neoplasms, Squamous Cell / genetics*
Neoplasms, Squamous Cell / immunology
Neoplasms, Squamous Cell / pathology
Neoplasms, Squamous Cell / virology
Papillomavirus Infections / genetics*
Papillomavirus Infections / immunology
Papillomavirus Infections / pathology
Papillomavirus Infections / virology
Polymorphism, Genetic
Risk Factors
Uterine Cervical Dysplasia / genetics*
Uterine Cervical Dysplasia / immunology
Uterine Cervical Dysplasia / pathology
Uterine Cervical Dysplasia / virology
Uterine Cervical Neoplasms / genetics*
Uterine Cervical Neoplasms / immunology
Uterine Cervical Neoplasms / pathology
Uterine Cervical Neoplasms / virology

Substances

3' Untranslated Regions
HLA-G Antigens