Abstract
Prc is a periplasmic protease involved in processing of penicillin-binding protein 3 (PBP3). Lack of Prc suppresses bile sensitivity in Dam-, Wec-, PhoP-, DamX-, and SeqA- mutants of Salmonella enterica, and increases bile resistance in the wild type. Changes in the activity of penicillin binding proteins PBP3, PBP4, PBP5/6 and PBP7 are detected in a Prc- background, suggesting that peptidoglycan remodeling might contribute to bile resistance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Bile / chemistry
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Bile Acids and Salts / pharmacology*
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Humans
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Mutation*
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Penicillin-Binding Proteins / genetics
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Penicillin-Binding Proteins / metabolism
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Peptide Hydrolases / deficiency*
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Peptide Hydrolases / genetics
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Periplasm / enzymology*
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Periplasm / genetics
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Salmonella typhimurium / drug effects*
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Salmonella typhimurium / enzymology*
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Salmonella typhimurium / genetics
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Bile Acids and Salts
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Penicillin-Binding Proteins
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Peptide Hydrolases