Abstract
We report a patient with relapsed acute myelogenous leukemia after allogeneic stem cell transplantation who developed disseminated mucormycosis due to Rhizomucor pusillus/R. miehei involving lung, brain, and skin. After failing posaconazole and being intolerant to amphotericin, he was treated effectively with isavuconazole for over 6 months despite ongoing treatment for relapsed leukemia.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antifungal Agents / therapeutic use*
-
Brain / microbiology
-
Brain / pathology
-
Humans
-
Immunocompromised Host
-
Leukemia, Myeloid, Acute / complications
-
Leukemia, Myeloid, Acute / therapy
-
Lung / microbiology
-
Lung / pathology
-
Male
-
Middle Aged
-
Mucormycosis / diagnosis*
-
Mucormycosis / drug therapy*
-
Mucormycosis / microbiology
-
Nitriles / therapeutic use*
-
Pyridines / therapeutic use*
-
Rhizomucor / isolation & purification*
-
Skin / microbiology
-
Skin / pathology
-
Stem Cell Transplantation / adverse effects
-
Transplantation, Homologous / adverse effects
-
Treatment Outcome
-
Triazoles / therapeutic use*
Substances
-
Antifungal Agents
-
Nitriles
-
Pyridines
-
Triazoles
-
isavuconazole