Isocitrate dehydrogenase (IDH)2 R140Q mutation induces myeloid and lymphoid neoplasms in mice

Leukemia. 2014 Jun;28(6):1343-6. doi: 10.1038/leu.2014.18. Epub 2014 Jan 14.

Authors

E Mylonas¹, M Janin², O Bawa³, P Opolon³, M David¹, C Quivoron¹, O A Bernard¹, C Ottolenghi², S DeBotton¹, V Penard-Lacronique¹

Affiliations

¹ 1] Institut National de la Santé et de la Recherche Médicale (INSERM) U985, Institut Gustave Roussy, Villejuif, France [2] Université Paris Sud-11, Orsay, France.
² 1] Biochimie métabolique, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Necker-Enfants Malades, Paris, France [2] INSERM U747, Université Paris Descartes, Paris, France.
³ Plateforme d'évaluation préclinique, Institut Gustave Roussy, Villejuif, France.

PMID: 24418992
DOI: 10.1038/leu.2014.18

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cells, Cultured
Hematologic Neoplasms / metabolism
Hematologic Neoplasms / pathology*
Hematopoietic Stem Cells / metabolism
Hematopoietic Stem Cells / pathology*
Humans
Isocitrate Dehydrogenase / genetics*
Lymphocytes / metabolism
Lymphocytes / pathology*
Mice
Mutation / genetics*
Myeloid Cells / metabolism
Myeloid Cells / pathology*
Retroviridae / genetics

Substances

IDH2 protein, human
Isocitrate Dehydrogenase