Canadian Society of Nephrology Commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis: management of glomerulonephritis in adults

Andrey V Cybulsky; Michael Walsh; Greg Knoll; Michelle Hladunewich; Joanne Bargman; Heather Reich; Atul Humar; Susan Samuel; Martin Bitzan; Michael Zappitelli; Allison Dart; Cherry Mammen; Maury Pinsk; Norman Muirhead

doi:10.1053/j.ajkd.2013.12.001

Canadian Society of Nephrology Commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis: management of glomerulonephritis in adults

Am J Kidney Dis. 2014 Mar;63(3):363-77. doi: 10.1053/j.ajkd.2013.12.001. Epub 2014 Jan 11.

Authors

Andrey V Cybulsky¹, Michael Walsh², Greg Knoll³, Michelle Hladunewich⁴, Joanne Bargman⁴, Heather Reich⁴, Atul Humar⁵, Susan Samuel⁶, Martin Bitzan⁷, Michael Zappitelli⁷, Allison Dart⁸, Cherry Mammen⁹, Maury Pinsk⁶, Norman Muirhead¹⁰

Affiliations

¹ Department of Medicine, McGill University, Montreal, Quebec.
² Division of Nephrology, Department of Medicine, McMaster University, Hamilton.
³ Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa.
⁴ Department of Medicine, University of Toronto, Toronto, Ontario.
⁵ Transplant Infectious Diseases, University of Alberta, Edmonton, Alberta.
⁶ Department of Pediatrics, University of Alberta, Edmonton, Alberta.
⁷ Montreal Children's Hospital, Montreal, Quebec.
⁸ Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba.
⁹ Department of Pediatrics, University of British Columbia, Vancouver, British Columbia.
¹⁰ Division of Nephrology, Department of Medicine, Western University, London, Ontario, Canada. Electronic address: [email protected].

PMID: 24423780
DOI: 10.1053/j.ajkd.2013.12.001

Abstract

The KDIGO (Kidney Disease: Improving Global Outcomes) clinical practice guideline for management of glomerulonephritis was recently released. The Canadian Society of Nephrology convened a working group to review the recommendations and comment on their relevancy and applicability to the Canadian context. A subgroup of adult nephrologists reviewed the guideline statements for management of glomerular disease in adults and agreed with most of the guideline statements developed by KDIGO. This commentary highlights areas for which there is lack of evidence and areas in need of translation of evidence into clinical practice. Areas of controversy or uncertainty, including the choice of second-line agents, are discussed in more detail. Existing practice variation also is addressed. The relevance of treatment recommendations to the Canadian practitioner is discussed.

Keywords: Canadian Society of Nephrology (CSN); Clinical practice guideline implementation; KDIGO (Kidney Disease: Improving Global Outcomes); glomerulonephritis; nephrotic syndrome.

Publication types

Review

MeSH terms

Adult
Canada
Disease Management*
Glomerulonephritis / therapy*
Humans
Nephrology*
Practice Guidelines as Topic*
Societies, Medical*