Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata

Misao Takemoto; Yumi Kawamura; Mikako Hirohama; Yuki Yamaguchi; Hiroshi Handa; Hisato Saitoh; Yoichi Nakao; Manabu Kawada; Khan Khalid; Hiroyuki Koshino; Ken-ichi Kimura; Akihiro Ito; Minoru Yoshida

doi:10.1038/ja.2013.142

Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata

J Antibiot (Tokyo). 2014 Apr;67(4):335-8. doi: 10.1038/ja.2013.142. Epub 2014 Jan 15.

Authors

Affiliations

¹ 1] Drug Discovery Platform Cooperation Division, RIKEN Center for Sustainable Resource Science, Wako, Japan [2] Department of Biological Information, Tokyo Institute of Technology, Yokohama, Japan.
² Graduate School of Agriculture, Iwate University, Morioka, Japan.
³ 1] Chemical Genetics Laboratory, RIKEN, Wako, Japan [2] Department of Chemistry and Biochemistry, Waseda University, Tokyo, Japan [3] Japan Science and Technology Corporation, CREST Research Project, Kawaguchi, Japan.
⁴ Department of Biological Information, Tokyo Institute of Technology, Yokohama, Japan.
⁵ Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.
⁶ Department of New Frontier Sciences, Graduate School of Science and Technology, Kumamoto University, Kumamoto, Japan.
⁷ Department of Chemistry and Biochemistry, Waseda University, Tokyo, Japan.
⁸ Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu, Japan.
⁹ Chemical Genetics Laboratory, RIKEN, Wako, Japan.
¹⁰ Global Research Cluster, RIKEN, Wako, Japan.
¹¹ 1] Chemical Genetics Laboratory, RIKEN, Wako, Japan [2] Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Japan.
¹² 1] Drug Discovery Platform Cooperation Division, RIKEN Center for Sustainable Resource Science, Wako, Japan [2] Chemical Genetics Laboratory, RIKEN, Wako, Japan [3] Japan Science and Technology Corporation, CREST Research Project, Kawaguchi, Japan [4] Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Japan.

PMID: 24424345
DOI: 10.1038/ja.2013.142

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / metabolism
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Cornaceae / chemistry*
Drug Discovery*
Humans
Hydrolyzable Tannins / chemistry
Hydrolyzable Tannins / isolation & purification
Hydrolyzable Tannins / metabolism
Hydrolyzable Tannins / pharmacology
Japan
Molecular Structure
Neoplasms / drug therapy*
Osmolar Concentration
Plant Extracts / chemistry
Plant Extracts / pharmacology
Plant Leaves / chemistry*
Sumoylation / drug effects*
Tannins / chemistry
Tannins / isolation & purification
Tannins / metabolism
Tannins / pharmacology*

Substances

Antineoplastic Agents, Phytogenic
Hydrolyzable Tannins
Plant Extracts
Tannins
davidiin