CARMA: CARM1 methylation of SWI/SNF in breast cancer

Xiaofeng Wang; Charles W M Roberts

doi:10.1016/j.ccr.2013.12.017

CARMA: CARM1 methylation of SWI/SNF in breast cancer

Cancer Cell. 2014 Jan 13;25(1):3-4. doi: 10.1016/j.ccr.2013.12.017.

Authors

Xiaofeng Wang¹, Charles W M Roberts²

Affiliations

¹ Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
² Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: [email protected].

Abstract

In this issue of Cancer Cell, Wang and colleagues report that CARM1, a protein arginine methyltransferase, specifically methylates BAF155/SMARCC1, a core subunit of the SWI/SNF chromatin remodeling/tumor suppressor complex. This modification facilitates the targeting of BAF155 to genes of the c-Myc pathway and enhances breast cancer progression and metastasis.

Publication types

Comment

MeSH terms

Animals
Breast Neoplasms / metabolism*
Female
Gene Expression Regulation, Neoplastic / physiology*
Humans
Protein-Arginine N-Methyltransferases / metabolism*
Transcription Factors / metabolism*

Substances

SMARCC1 protein, human
Smarcc1 protein, mouse
Transcription Factors
Protein-Arginine N-Methyltransferases
coactivator-associated arginine methyltransferase 1

Abstract

Publication types

MeSH terms

Substances

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