In this issue of Blood, 2 articles by The Nimes Obstetricians and Hematologists–Antiphospholipid Syndrome (NOH-APS) Study Group give us new information about the effects of low-molecular-weight heparin (LMWH) on pregnancy complications in women with prior pregnancy loss and either purely obstetric antiphospholipid syndrome (APS) or inherited thrombophilia. The results better define women at risk, suggest a role for LMWH, and confirm the need for further investigation.