Hyperthermia-induced drug delivery from thermosensitive liposomes encapsulated in an injectable hydrogel for local chemotherapy

Adv Healthc Mater. 2014 Jun;3(6):854-9. doi: 10.1002/adhm.201300649. Epub 2014 Jan 16.

Abstract

A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy.

Keywords: chemotherapy; chitosan hydrogels; hyperthermia; liposomes; thermoresponsive.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Chitosan / chemistry
  • Doxorubicin / chemistry
  • Doxorubicin / metabolism
  • Doxorubicin / pharmacology
  • Glycerophosphates / chemistry
  • Humans
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
  • Liposomes / chemistry*
  • Temperature

Substances

  • Glycerophosphates
  • Liposomes
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Doxorubicin
  • Chitosan