Abstract
A synthesis of natural and synthetic members of the meridianin family of kinase inhibitory natural products has been developed. The sequence utilizes a variation of the Cacchi palladium-catalyzed domino reaction to efficiently construct the heterocyclic framework of the meridianins and meriolins from monocyclic precursors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
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Bridged Bicyclo Compounds, Heterocyclic / chemistry*
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Catalysis
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Heterocyclic Compounds, 1-Ring / chemical synthesis*
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Heterocyclic Compounds, 1-Ring / chemistry*
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Indole Alkaloids / chemical synthesis*
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Indole Alkaloids / chemistry*
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Molecular Structure
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Palladium / chemistry*
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Pyrimidines / chemical synthesis*
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Pyrimidines / chemistry*
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Stereoisomerism
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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Heterocyclic Compounds, 1-Ring
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Indole Alkaloids
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Pyrimidines
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meridianin A
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meriolin 3
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Palladium