Abstract
A new sesquilignan glucoside, urariasinoside A (1), together with eight known compounds, including two lignans, a sesquilignan, a dilignan, and four flavonoid derivatives were isolated from the aerial parts of Uraria sinensis. Their structures were determined on the basis of extensive spectroscopic analyses and comparison with literature data. Compound 1 was evaluated for in vitro cytotoxicity activity against HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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Fabaceae / chemistry*
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Glucosides / chemistry*
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Glucosides / isolation & purification
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Glucosides / pharmacology
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HL-60 Cells
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Humans
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Lignans / chemistry*
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Lignans / isolation & purification
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Lignans / pharmacology
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MCF-7 Cells
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Plant Components, Aerial / chemistry*
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Plant Extracts / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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Glucosides
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Lignans
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Plant Extracts