Abstract
Vancomycin trough serum concentrations were below therapeutic range (8-15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.
MeSH terms
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Adolescent
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Anti-Bacterial Agents / administration & dosage*
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Anti-Bacterial Agents / pharmacokinetics*
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Anti-Bacterial Agents / pharmacology
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Bacterial Infections / drug therapy
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Child
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Child, Preschool
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Female
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Humans
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Infant
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Male
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Neoplasms / complications
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Retrospective Studies
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Serum / chemistry
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Vancomycin / administration & dosage*
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Vancomycin / pharmacokinetics*
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Vancomycin / pharmacology
Substances
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Anti-Bacterial Agents
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Vancomycin