Teaching neuroimages: neonatal parechovirus encephalitis: typical MRI findings

Vincenzo Belcastro; Paolo Bini; Roberta Barachetti; Mario Barbarini

doi:10.1212/WNL.0000000000000040

Teaching neuroimages: neonatal parechovirus encephalitis: typical MRI findings

Neurology. 2014 Jan 21;82(3):e23. doi: 10.1212/WNL.0000000000000040.

Authors

Vincenzo Belcastro¹, Paolo Bini, Roberta Barachetti, Mario Barbarini

Affiliation

¹ From the Departments of Neurosciences (V.B.) and Neonatology (P.B., R.B., M.B.), S. Anna Hospital, Como, Italy.

PMID: 24446179
DOI: 10.1212/WNL.0000000000000040

Abstract

A full-term 9-day-old girl presented with fever, irritability, and seizures. The routine CSF examination, cranial ultrasound, and laboratory tests were normal. Brain MRI showed diffuse white matter abnormality (figure). Human parechovirus (HPeV) type 3 was isolated in both CSF and blood. The neurodevelopmental outcome at 4 months is poor, and MRI shows an extensive cystic leukomalacia in the frontal white matter.

Publication types

Case Reports

MeSH terms

Encephalitis / etiology*
Encephalitis / pathology
Encephalitis / virology
Female
Humans
Infant, Newborn
Leukoencephalopathies / etiology*
Leukoencephalopathies / pathology
Leukoencephalopathies / virology
Magnetic Resonance Imaging / methods
Neuroimaging / methods
Neurology / education
Parechovirus / pathogenicity*
Picornaviridae Infections / blood
Picornaviridae Infections / cerebrospinal fluid
Picornaviridae Infections / complications*
Picornaviridae Infections / pathology