Abstract
We explored associations between Plasmodium falciparum drug resistance-mediating polymorphisms and clinical presentations in parasitemic children enrolled in a cross-sectional survey in Tororo, Uganda, using a retrospective case-control design. All 243 febrile children (cases) and 243 randomly selected asymptomatic children (controls) were included. In a multivariate analysis adjusting for age, complexity of infection, and parasite density, the prevalence of wild-type genotypes was significantly higher in febrile children compared to asymptomatic children (pfcrt K76T: odds ratio [OR] 4.41 [95% confidence interval {CI}, 1.28-15.1]; pfmdr1 N86Y: OR 4.08 [95% CI, 2.01-8.31], and pfmdr1 D1246Y: OR 4.90 [95% CI, 1.52-15.8]), suggesting greater virulence for wild-type parasites.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Case-Control Studies
-
Child
-
Child, Preschool
-
Cross-Sectional Studies
-
Drug Resistance*
-
Female
-
Humans
-
Infant
-
Malaria, Falciparum / parasitology*
-
Malaria, Falciparum / pathology*
-
Male
-
Membrane Transport Proteins / genetics
-
Multidrug Resistance-Associated Proteins / genetics
-
Plasmodium falciparum / drug effects*
-
Plasmodium falciparum / genetics*
-
Plasmodium falciparum / isolation & purification
-
Plasmodium falciparum / pathogenicity
-
Polymorphism, Genetic*
-
Protozoan Proteins / genetics
-
Retrospective Studies
-
Uganda
-
Virulence
Substances
-
Mdr1 protein, Plasmodium falciparum
-
Membrane Transport Proteins
-
Multidrug Resistance-Associated Proteins
-
PfCRT protein, Plasmodium falciparum
-
Protozoan Proteins