The FIP1L1-PDGFRA fusion gene and the KIT D816V mutation are coexisting in a small subset of myeloid/lymphoid neoplasms with eosinophilia

Blood. 2014 Jan 23;123(4):595-7. doi: 10.1182/blood-2013-10-530642.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biopsy
  • Bone Marrow Cells / cytology
  • CD2 Antigens / metabolism
  • Eosinophilia / metabolism*
  • Gene Deletion
  • Gene Expression Regulation
  • Humans
  • Hypereosinophilic Syndrome / metabolism*
  • Interleukin-2 Receptor alpha Subunit / metabolism
  • Leukemia
  • Leukemia, Myeloid, Acute / metabolism
  • Mutation
  • Oncogene Proteins, Fusion / metabolism*
  • Polymerase Chain Reaction
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • Proto-Oncogene Proteins c-kit / genetics*
  • Proto-Oncogene Proteins c-kit / metabolism
  • Receptor, Platelet-Derived Growth Factor alpha / metabolism*
  • Sarcoma, Myeloid / metabolism
  • Tryptases / metabolism
  • mRNA Cleavage and Polyadenylation Factors / metabolism*

Substances

  • CD2 Antigens
  • FIP1L1 protein, human
  • Interleukin-2 Receptor alpha Subunit
  • Oncogene Proteins, Fusion
  • mRNA Cleavage and Polyadenylation Factors
  • Proto-Oncogene Proteins c-kit
  • Receptor, Platelet-Derived Growth Factor alpha
  • Tryptases

Supplementary concepts

  • Pdgfra-Associated Chronic Eosinophilic Leukemia