Reversible posterior leukoencephalopathy syndrome during regorafenib treatment: a case report and literature review of reversible posterior leukoencephalopathy syndrome associated with multikinase inhibitors

Clin Colorectal Cancer. 2014 Jun;13(2):127-30. doi: 10.1016/j.clcc.2013.12.003. Epub 2013 Dec 27.
No abstract available

Keywords: Metastatic colorectal cancer; Posterior reversible encephalopathy; RPLS; Regorafenib; VEGF multikinase inhibitor; syndrome.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Angiogenesis Inhibitors / adverse effects
  • Angiogenesis Inhibitors / pharmacology
  • Angiogenesis Inhibitors / therapeutic use
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Colorectal Neoplasms / drug therapy
  • Colorectal Neoplasms / pathology
  • Humans
  • Male
  • Neoplasm Metastasis
  • Phenylurea Compounds / adverse effects*
  • Phenylurea Compounds / pharmacology
  • Phenylurea Compounds / therapeutic use
  • Posterior Leukoencephalopathy Syndrome / chemically induced*
  • Posterior Leukoencephalopathy Syndrome / physiopathology
  • Pyridines / adverse effects*
  • Pyridines / pharmacology
  • Pyridines / therapeutic use

Substances

  • Angiogenesis Inhibitors
  • Antineoplastic Agents
  • Phenylurea Compounds
  • Pyridines
  • regorafenib