Tc1 clonal T cell expansion during chronic graft-versus-host disease-associated hypereosinophilia

Emmanuel Clave; Aliénor Xhaard; Corrine Douay; Lionel Adès; Jean Michel Cayuela; Régis Peffault de Latour; Marie Robin; Antoine Toubert; Gérard Socié

doi:10.1016/j.bbmt.2014.01.023

Tc1 clonal T cell expansion during chronic graft-versus-host disease-associated hypereosinophilia

Biol Blood Marrow Transplant. 2014 May;20(5):739-42. doi: 10.1016/j.bbmt.2014.01.023. Epub 2014 Jan 24.

Authors

Emmanuel Clave¹, Aliénor Xhaard², Corrine Douay¹, Lionel Adès³, Jean Michel Cayuela⁴, Régis Peffault de Latour², Marie Robin², Antoine Toubert⁵, Gérard Socié⁶

Affiliations

¹ Departement d'Immunologie, INSERM UMRS-940, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
² Service d'Hématologie-Greffe, AP-HP Hôpital Saint Louis, Paris, France.
³ Service d'Hématologie, AP-HP Hôpital Avicenne, Paris, France.
⁴ Service d'Hématologie Biologique, AP-HP Hôpital Saint Louis, Paris, France.
⁵ Departement d'Immunologie, INSERM UMRS-940, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France; Service d'Immunologie, AP-HP Hôpital Saint Louis, Paris, France.
⁶ Departement d'Immunologie, INSERM UMRS-940, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France; Service d'Hématologie-Greffe, AP-HP Hôpital Saint Louis, Paris, France. Electronic address: [email protected].

PMID: 24468638
DOI: 10.1016/j.bbmt.2014.01.023

Abstract

Although hypereosinophilia (HE) associated with chronic graft-versus-host disease (GVHD) has long been recognized, biological data on this phenomenon are scarce. Here we compare patients with chronic GVHD with HE together with a clonal T cell expansion and control patients with acute or chronic GVHD but without HE. These clonal expansions share a CD8(+) TC1 phenotype rather than a CD4(+) Th2 profile. In contrast to the drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, these allogeneic CD8(+) clones do not recognize the epitopes of herpesviruses. Furthermore, these TC1 clones do not produce IL-17 as described in the DRESS syndrome.

Keywords: Eosinophilia; Graft-versus-host disease.

MeSH terms

Adult
Antineoplastic Agents / therapeutic use
Cell Proliferation
Chronic Disease
Clone Cells
Eosinophilia / complications
Eosinophilia / immunology
Eosinophilia / pathology*
Eosinophils / immunology
Eosinophils / pathology
Female
Graft vs Host Disease / complications
Graft vs Host Disease / immunology
Graft vs Host Disease / pathology*
Hematologic Neoplasms / immunology
Hematologic Neoplasms / pathology*
Hematologic Neoplasms / therapy
Humans
Immunophenotyping
Male
Peripheral Blood Stem Cell Transplantation*
T-Lymphocytes / immunology
T-Lymphocytes / pathology*

Substances

Antineoplastic Agents