Cloning and characterization of a dynein light chain gene from Puccinia striiformis f. sp. tritici

J Basic Microbiol. 2014 Jul:54 Suppl 1:S32-41. doi: 10.1002/jobm.201300645. Epub 2014 Jan 28.

Abstract

Stripe rust is one of the most serious wheat diseases worldwide. The fungus Puccinia striiformis f. sp. tritici (Pst), the causal agent of this disease, is an obligate biotrophic basidiomycete fungus. Numerous studies have shown that dyneins play important roles during fungal growth and propagation. However, knowledge is limited regarding the function of dyneins in Pst. In this study, we cloned the dynein light chain gene PsDLC1 from Pst and characterized its expression. The function of PsDLC1 was determined by heterologous mutant complementation. Expression of PsDLC1 in Aspergillus nidulans partially complemented the defects of the ΔnudG mutant, indicating that PsDLC1 belongs to the dynein light chain LC8 family. In addition, PsDLC1 was identified in Pst using virus-induced gene silencing (VIGS). Knockdown of PsDLC1 produces no significant effect on Pst growth and development, indicating that PsDLC1 is unnecessary for Pst infection of wheat.

Keywords: Dynein; Light chain 8; Puccinia striiformis f. sp. tritici; Stripe rust.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus nidulans / genetics
  • Aspergillus nidulans / growth & development
  • Basidiomycota / genetics*
  • Basidiomycota / growth & development*
  • Basidiomycota / isolation & purification
  • Cloning, Molecular
  • Dyneins / genetics*
  • Dyneins / metabolism*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Gene Deletion
  • Gene Expression Profiling
  • Gene Knockdown Techniques
  • Genetic Complementation Test
  • Plant Diseases / microbiology
  • Protein Subunits / genetics
  • Protein Subunits / metabolism
  • Triticum / microbiology

Substances

  • Fungal Proteins
  • Protein Subunits
  • Dyneins