Abstract
Context:
Cardiac surgery.
Objective:
To compare plasma and urinary neutrophil gelatinase-associated lipocalin (P-/U-NGAL) in on-pump (n = 43) versus off-pump (n = 40) surgery.
Materials and methods:
We obtained perioperative P-/U-NGAL and outcome data.
Results:
P-/U-NGAL increased after surgery. P-NGAL was higher post-surgery in on pump patients (139 versus 67 µg L(-1); p < 0.001), but not at 24 h. There were no differences in U-NGAL. Correlation between P-/U-NGAL and plasma creatinine was weak.
Discussion:
P-NGAL acts like a neutrophil activation biomarker and U-NGAL like a tubular injury marker.
Conclusion:
On-pump patients had greater neutrophil activation. On- versus off-pump surgery had similar impact on tubular cells.
Publication types
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Comparative Study
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Observational Study
MeSH terms
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Acute Kidney Injury / blood
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Acute Kidney Injury / etiology
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Acute Kidney Injury / urine
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Acute-Phase Proteins / urine
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Aged
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Biomarkers / blood
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Biomarkers / urine
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Cardiopulmonary Bypass / adverse effects
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Coronary Artery Disease / blood*
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Coronary Artery Disease / surgery
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Coronary Artery Disease / urine
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Creatinine / blood
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Female
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Humans
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Kidney Transplantation
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Lipocalin-2
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Lipocalins / blood*
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Lipocalins / urine
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Male
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Middle Aged
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Postoperative Complications / blood*
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Postoperative Complications / urine
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Prospective Studies
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Proto-Oncogene Proteins / blood*
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Proto-Oncogene Proteins / urine
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Treatment Outcome
Substances
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Acute-Phase Proteins
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Biomarkers
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LCN2 protein, human
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Lipocalin-2
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Lipocalins
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Proto-Oncogene Proteins
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Creatinine