Abstract
Visual evoked potentials were studied in 11 patients with neuropathy and macroglobulinemia. The P100 latency was increased bilaterally in 5 of the 6 patients whose IgM M-proteins reacted with myelin-associated glycoprotein (MAG) and in 1 of the other patients. In patients whose M-protein bound to MAG, abnormal visual evoked potentials correlated with the presence of the M-protein in the cerebrospinal fluid. Subclinical involvement of the central nervous system is frequent in patients with neuropathy and anti-MAG M-proteins and may be due to the binding of M-proteins to central nervous system myelin.
MeSH terms
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Aged
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Blood Proteins / cerebrospinal fluid*
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Blood Proteins / immunology
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Evoked Potentials, Visual*
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Female
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Humans
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Immunoglobulins*
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Male
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Middle Aged
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Myelin Proteins / cerebrospinal fluid
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Myelin Proteins / immunology
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Myelin-Associated Glycoprotein
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Peripheral Nervous System Diseases / cerebrospinal fluid
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Peripheral Nervous System Diseases / immunology
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Peripheral Nervous System Diseases / physiopathology*
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Waldenstrom Macroglobulinemia / cerebrospinal fluid
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Waldenstrom Macroglobulinemia / immunology
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Waldenstrom Macroglobulinemia / physiopathology*
Substances
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Blood Proteins
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Immunoglobulins
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M-proteins (Myeloma)
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Myelin Proteins
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Myelin-Associated Glycoprotein