Safety and immunogenicity of booster immunization with 7-valent pneumococcal conjugate vaccine in children with idiopathic nephrotic syndrome

Vaccine. 2014 Mar 10;32(12):1394-7. doi: 10.1016/j.vaccine.2013.11.106. Epub 2014 Jan 30.

Abstract

Safety and immunogenicity of a booster dose of 7-valent pneumococcal conjugate vaccine (PCV7) were evaluated in 29 patients with idiopathic nephrotic syndrome (INS), who had been primed 12 months earlier with one dose of PCV7. PCV7 was not associated with increased risk of INS relapse (RR=0.77, p=0.8) and serotype-specific antibodies increased in all subjects at 1 month (p<0.01). The quantitative characteristics of immune response and the effect of treatment with mycophenolate mofetil and/or cyclosporine A following booster PCV7 were similar with primary response. Additional PCV7 doses could be safely given in children with INS to increase circulating antibodies above the protective threshold.

Keywords: Booster vaccination; Idiopathic nephrotic syndrome; Pneumococcal conjugate vaccine; Safety.

MeSH terms

  • Adolescent
  • Antibodies, Bacterial / blood
  • Child
  • Cyclosporine / therapeutic use
  • Female
  • Follow-Up Studies
  • Heptavalent Pneumococcal Conjugate Vaccine
  • Humans
  • Immunization, Secondary*
  • Immunoglobulin G / blood
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Mycophenolic Acid / analogs & derivatives
  • Mycophenolic Acid / therapeutic use
  • Nephrotic Syndrome / therapy*
  • Pneumococcal Infections / prevention & control*
  • Pneumococcal Vaccines / administration & dosage*
  • Prospective Studies

Substances

  • Antibodies, Bacterial
  • Heptavalent Pneumococcal Conjugate Vaccine
  • Immunoglobulin G
  • Immunosuppressive Agents
  • Pneumococcal Vaccines
  • Cyclosporine
  • Mycophenolic Acid

Supplementary concepts

  • Nephrosis, congenital