Peripheral blood lymphocytes from patients with bipolar disorder demonstrate apoptosis and differential regulation of advanced glycation end products and S100B

Clin Chem Lab Med. 2014 Jul;52(7):999-1007. doi: 10.1515/cclm-2013-0978.

Abstract

Background: This study addresses the expression of the glycosylated proteins known as advanced glycation end products (AGEs), the calcium binding protein S100B and the apoptotic parameters cytochome c and caspase-3 activity in peripheral lymphocyte cytosolic extracts from a sample of bipolar disorder (BD) patients and healthy (control) subjects.

Methods: Cross-sectional study of 35 patients with a clinical diagnosis of bipolar disease (10 euthymic, 12 depressed, 13 manic) and 10 healthy control subjects. Lymphocytes were used as a surrogate model in BD diagnosis and treatment. AGEs and S100B in lymphocyte cell extracts were measured by commercially available enzyme-linked immunosorbent assay.

Results: AGEs were lower in all BD patients compared to healthy subjects. Depressed patients had approximately two-fold higher S100B levels compared to healthy subjects. Manic and depressed BD patients had increased superoxide dismutase mRNA levels. Apoptosis as measured by BAX/Bcl2 ratio, cytochrome c release, caspase-3 activity was increased in manic and depressed patients compared to healthy subjects. In the depressed patients, S100B levels correlated with cytochrome c release.

Conclusions: In conclusion, our study shows decreased AGEs and increased S100B levels and caspase down-stream apoptosis in peripheral lymphocytes of BD patients that may underlie disease etiopathogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Apoptosis*
  • Bipolar Disorder / blood*
  • Bipolar Disorder / metabolism*
  • Bipolar Disorder / pathology
  • Female
  • Glycation End Products, Advanced / analysis
  • Glycation End Products, Advanced / metabolism*
  • Humans
  • Lymphocytes / metabolism*
  • Lymphocytes / pathology*
  • Male
  • Middle Aged
  • S100 Calcium Binding Protein beta Subunit / analysis
  • S100 Calcium Binding Protein beta Subunit / metabolism*
  • Young Adult

Substances

  • Glycation End Products, Advanced
  • S100 Calcium Binding Protein beta Subunit
  • S100B protein, human