Abstract
The expression of the murine CD2 gene and the interleukin 2 receptor IL2R has been investigated during fetal thymus ontogeny. CD2 mRNA was undetectable at embryonic day 14 but was readily detectable at day 15 of gestation. Surface IL2R expression was maximal at day 14 and was clearly detectable at day 13. These results indicate that IL2R expression precedes that of CD2 by at least 2 days.
MeSH terms
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Animals
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CD2 Antigens
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Carrier Proteins / genetics*
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Embryonic and Fetal Development*
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Genes, MHC Class II*
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Mice
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Mice, Inbred CBA
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RNA / isolation & purification
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Receptors, Immunologic / analysis
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Receptors, Immunologic / genetics*
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Receptors, Interleukin-2
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T-Lymphocytes / cytology
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T-Lymphocytes / metabolism
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Thymus Gland / cytology
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Thymus Gland / growth & development
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Thymus Gland / metabolism*
Substances
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CD2 Antigens
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Carrier Proteins
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Receptors, Immunologic
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Receptors, Interleukin-2
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RNA