Left-invariant metrics for diffeomorphic image registration with spatially-varying regularisation

Med Image Comput Comput Assist Interv. 2013;16(Pt 1):203-10. doi: 10.1007/978-3-642-40811-3_26.

Abstract

We present a new framework for diffeomorphic image registration which supports natural interpretations of spatially-varying metrics. This framework is based on left-invariant diffeomorphic metrics (LIDM) and is closely related to the now standard large deformation diffeomorphic metric mapping (LDDMM). We discuss the relationship between LIDM and LDDMM and introduce a computationally convenient class of spatially-varying metrics appropriate for both frameworks. Finally, we demonstrate the effectiveness of our method on a 2D toy example and on the 40 3D brain images of the LPBA40 dataset.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Brain / anatomy & histology*
  • Humans
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods*
  • Magnetic Resonance Imaging / methods*
  • Pattern Recognition, Automated / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Subtraction Technique*