Noninvasive ventilation and lung volume reduction

Patrick Brian Murphy; Zaid Zoumot; Michael Iain Polkey

doi:10.1016/j.ccm.2013.10.011

Noninvasive ventilation and lung volume reduction

Clin Chest Med. 2014 Mar;35(1):251-69. doi: 10.1016/j.ccm.2013.10.011.

Authors

Patrick Brian Murphy¹, Zaid Zoumot², Michael Iain Polkey³

Affiliations

¹ Lane Fox Clinical Respiratory Physiology Group, Guy's & St Thomas' NHS Foundation Trust, London, UK.
² NIHR Respiratory Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, Imperial College London, London, UK.
³ NIHR Respiratory Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, Imperial College London, London, UK. Electronic address: [email protected].

PMID: 24507850
DOI: 10.1016/j.ccm.2013.10.011

Abstract

As parenchymal lung disease in chronic obstructive pulmonary disease becomes increasingly severe there is a diminishing prospect of drug therapies conferring clinically useful benefit. Lung volume reduction surgery is effective in patients with heterogenous upper zone emphysema and reduced exercise tolerance, and is probably underused. Rapid progress is being made in nonsurgical approaches to lung volume reduction, but use outside specialized centers cannot be recommended presently. Noninvasive ventilation given to patients with acute hypercapnic exacerbation of chronic obstructive pulmonary disease reduces mortality and morbidity, but the place of chronic non-invasive ventilatory support remains more controversial.

Keywords: Collateral ventilation; Emphysema; Lung volume reduction surgery; Noninvasive ventilation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bronchoscopy
Humans
Hypercapnia / therapy
Lung / physiopathology
Lung / surgery
Noninvasive Ventilation* / methods
Pneumonectomy* / methods
Pulmonary Disease, Chronic Obstructive / surgery
Pulmonary Disease, Chronic Obstructive / therapy*
Pulmonary Emphysema / surgery*