Abstract
An efficient and regioselective synthesis of novel functionalized dispiropyrrolizidine derivatives via a three-component [3 + 2] cycloaddition reaction of azomethine ylides is described. This protocol has the advantages of high efficiency, mild reaction conditions, a one-pot procedure, and convenient operation. Many of these compounds were evaluated for their antiproliferative properties in vitro against cancer cells and several compounds were found to have good activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Proliferation / drug effects
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Combinatorial Chemistry Techniques
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Cyclization
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Hep G2 Cells
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Humans
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Models, Molecular
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Molecular Structure
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Pyrrolizidine Alkaloids / chemical synthesis
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Pyrrolizidine Alkaloids / chemistry
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Pyrrolizidine Alkaloids / pharmacology*
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Spiro Compounds / chemical synthesis
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Spiro Compounds / chemistry
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Spiro Compounds / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Pyrrolizidine Alkaloids
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Spiro Compounds