Safety and efficacy of adding sitagliptin to insulin in patients with type 2 diabetes: the ASSIST-K study

Masahiko Takai; Masashi Ishikawa; Hajime Maeda; Akira Kanamori; Akira Kubota; Hikaru Amemiya; Takashi Iizuka; Kotaro Iemitsu; Tomoyuki Iwasaki; Goro Uehara; Shinichi Umezawa; Mitsuo Obana; Hideaki Kaneshige; Mizuki Kaneshiro; Takehiro Kawata; Nobuo Sasai; Tatsuya Saito; Tetsuo Takuma; Hiroshi Takeda; Keiji Tanaka; Nobuaki Tsurui; Shigeru Nakajima; Kazuhiko Hoshino; Shin Honda; Hideo Machimura; Kiyokazu Matoba; Fuyuki Minagawa; Nobuaki Minami; Yukiko Miyairi; Atsuko Mokubo; Tetsuya Motomiya; Manabu Waseda; Masaaki Miyakawa; Yoshikazu Naka; Yasuo Terauchi; Yasushi Tanaka; Ikuro Matsuba

doi:10.1016/j.diabres.2013.12.045

Safety and efficacy of adding sitagliptin to insulin in patients with type 2 diabetes: the ASSIST-K study

Diabetes Res Clin Pract. 2014 Mar;103(3):e30-3. doi: 10.1016/j.diabres.2013.12.045. Epub 2014 Jan 6.

Authors

Masahiko Takai¹, Masashi Ishikawa¹, Hajime Maeda¹, Akira Kanamori¹, Akira Kubota¹, Hikaru Amemiya¹, Takashi Iizuka¹, Kotaro Iemitsu¹, Tomoyuki Iwasaki¹, Goro Uehara¹, Shinichi Umezawa¹, Mitsuo Obana¹, Hideaki Kaneshige¹, Mizuki Kaneshiro¹, Takehiro Kawata¹, Nobuo Sasai¹, Tatsuya Saito¹, Tetsuo Takuma¹, Hiroshi Takeda¹, Keiji Tanaka¹, Nobuaki Tsurui¹, Shigeru Nakajima¹, Kazuhiko Hoshino¹, Shin Honda¹, Hideo Machimura¹, Kiyokazu Matoba¹, Fuyuki Minagawa¹, Nobuaki Minami¹, Yukiko Miyairi¹, Atsuko Mokubo¹, Tetsuya Motomiya¹, Manabu Waseda¹, Masaaki Miyakawa¹, Yoshikazu Naka¹, Yasuo Terauchi², Yasushi Tanaka³, Ikuro Matsuba⁴

Affiliations

¹ The Study Group of the Diabetes Committee, Kanagawa Physicians Association, Kanagawa, Japan.
² Department of Endocrinology and Metabolism, Yokohama City University, Kanagawa, Japan.
³ Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine, Kanagawa, Japan.
⁴ The Study Group of the Diabetes Committee, Kanagawa Physicians Association, Kanagawa, Japan. Electronic address: [email protected].

PMID: 24525293
DOI: 10.1016/j.diabres.2013.12.045

Abstract

We retrospectively studied more than 1000 patients with type 2 diabetes attending 36 Japanese clinics to investigate the efficacy and safety of adding sitagliptin to various insulin regimens. We found that the treatment with add-on sitagliptin for 6-months was effective, irrespective of the type or dose of concomitant insulin.

Keywords: Glycemic control; Insulin; Sitagliptin; Type 2 diabetes.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Asian People
Diabetes Mellitus, Type 2 / drug therapy*
Drug Therapy, Combination
Female
Glycated Hemoglobin / analysis
Humans
Hypoglycemic Agents / therapeutic use*
Insulin / therapeutic use*
Male
Middle Aged
Prognosis
Pyrazines / therapeutic use*
Retrospective Studies
Sitagliptin Phosphate
Triazoles / therapeutic use*

Substances

Glycated Hemoglobin A
Hypoglycemic Agents
Insulin
Pyrazines
Triazoles
Sitagliptin Phosphate