Drug effects on arthrosis. Comparison in rabbits of 3 modes of action

Acta Orthop Scand. 1988 Apr;59(2):186-90. doi: 10.1080/17453678809169706.

Abstract

Arthrosis was induced in adult rabbit knees by immobilization in extension. The influence of some intraarticularly injected drugs on the course of arthrosis was studied. Arteparon, Trasylol, and Kenacort A10 increased the contents of acidic glycosaminoglycans in the chondrocytes. Only Arteparon had a favorable effect on the integrity of the articular surface.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Topical
  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / therapeutic use*
  • Aprotinin / administration & dosage
  • Aprotinin / therapeutic use*
  • Cartilage, Articular / drug effects
  • Glucocorticoids
  • Glycosaminoglycans / administration & dosage
  • Glycosaminoglycans / therapeutic use
  • Injections, Intra-Articular
  • Osteoarthritis / drug therapy*
  • Rabbits

Substances

  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Glycosaminoglycans
  • Arteparon
  • Aprotinin