Abstract
This invited review summarizes work presented in the Russell Ross lecture delivered at the 2012 proceedings of the American Heart Association. We begin with a brief overview of the structural, cellular, and molecular biology of Krüppel-like factors. We then focus on discoveries during the past decade, implicating Krüppel-like factors as key determinants of vascular cell function in atherosclerotic vascular disease.
Keywords:
Krüppel-like transcription factors; atherosclerosis.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Atherosclerosis / genetics
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Atherosclerosis / immunology
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Atherosclerosis / metabolism*
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Atherosclerosis / pathology
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DNA / metabolism
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Disease Progression
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Endothelial Cells / metabolism
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Endothelial Cells / pathology
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Endothelium, Vascular / metabolism
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Endothelium, Vascular / physiopathology
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Foam Cells / metabolism
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Gene Expression Regulation
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Hemorheology
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Humans
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Inflammation
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Kruppel-Like Transcription Factors / chemistry
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Kruppel-Like Transcription Factors / physiology*
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Lymphocyte Subsets / metabolism
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Mice
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Mice, Knockout
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Models, Cardiovascular
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Myocytes, Smooth Muscle / metabolism
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Nuclear Proteins / metabolism
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Protein Binding
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Structure-Activity Relationship
Substances
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Kruppel-Like Transcription Factors
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Nuclear Proteins
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DNA