Linked in: formation and regulation of microtubule attachments during chromosome segregation

Dhanya K Cheerambathur; Arshad Desai

doi:10.1016/j.ceb.2013.12.005

Linked in: formation and regulation of microtubule attachments during chromosome segregation

Curr Opin Cell Biol. 2014 Feb:26:113-22. doi: 10.1016/j.ceb.2013.12.005. Epub 2014 Jan 7.

Authors

Dhanya K Cheerambathur¹, Arshad Desai²

Affiliations

¹ Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: [email protected].
² Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: [email protected].

Abstract

Accurate segregation of the replicated genome during cell division depends on dynamic attachments formed between chromosomes and the microtubule polymers of the spindle. Here we review recent advances in mechanistic analysis of microtubule attachment formation and regulation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Chromosome Segregation*
Humans
Kinetochores*
Microtubules / chemistry
Microtubules / genetics
Microtubules / physiology*
Nuclear Proteins / metabolism
Protein Binding

Substances

Nuclear Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding