Tumor evolution in response to chemotherapy: phenotype versus genotype

Nicholas E Navin

doi:10.1016/j.celrep.2014.01.035

Tumor evolution in response to chemotherapy: phenotype versus genotype

Cell Rep. 2014 Feb 13;6(3):417-9. doi: 10.1016/j.celrep.2014.01.035.

Author

Nicholas E Navin¹

Affiliation

¹ Department of Genetics, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: [email protected].

Abstract

In this issue of Cell Reports, Almendro et al. report one of the first comprehensive studies on the intratumor heterogeneity of cell phenotypes and genotypes before and after chemotherapy in breast cancer. These data challenge the concept of genetic population bottlenecks and suggest that cellular phenotypes play an important role in developing resistance to therapy.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Antineoplastic Agents / therapeutic use*
Breast Neoplasms / drug therapy*
Breast Neoplasms / genetics*
Female
Genetic Variation*
Humans

Substances

Antineoplastic Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding