Line-associated thrombosis as the major cause of hospital-acquired deep vein thromboses: an analysis from National Surgical Quality Improvement Program data and a call to reassess prophylaxis strategies

Am J Surg. 2014 Jul;208(1):45-9. doi: 10.1016/j.amjsurg.2013.08.046. Epub 2014 Jan 4.

Abstract

Background: Quality improvement has mitigated the occurrence of postoperative deep vein thromboses (DVTs); however, despite adherence to protocols, they continue to occur. This study aimed to characterize their rate and distribution at our institution, and appropriate use of thromboprophylaxis.

Methods: Local American College of Surgeons National Surgical Quality Improvement Program data were queried for general surgery cases complicated by DVT from 2009 to 2011. Medical records were evaluated to ascertain the following: classify DVTs by site, ascertain if appropriate prophylactic measures were instituted, evaluate treatment instituted, evaluate the occurrence of a PE if the DVT was line-associated, and if so, the indication for the central line.

Results: Of 1,857 patients, 39 had postoperative DVTs (2.1%). Fourteen lower-extremity (35.9%) DVTs, 4 central (10%) DVTs, and 21 upper-extremity (53.8%) DVTs (UEDVTs) were captured. All but 2 had appropriate thromboprophylaxis. All but one UEDVT was line-associated. Diagnoses were prompted by symptoms in 72% of the patients. Pulmonary emboli developed in 3 of 39 patients.

Conclusions: An unexpected finding was that line-associated UEDVTs comprised over half of all DVTs, mostly in patients without cancer. This analysis highlights the need for more selective central-line use; choosing peripheral access may reduce DVT rates further. Improved pharmacoprophylaxis protocols would likely benefit this population.

Keywords: Central venous catheter; Deep vein thrombosis; Thromboprophylaxis; Upper-extremity thrombosis; Venous thromboembolus.

Publication types

  • Evaluation Study

MeSH terms

  • Catheterization, Central Venous / adverse effects*
  • Databases, Factual
  • Fibrinolytic Agents / therapeutic use
  • Humans
  • Middle Aged
  • Postoperative Complications / epidemiology
  • Postoperative Complications / etiology*
  • Postoperative Complications / prevention & control
  • Pulmonary Embolism / epidemiology
  • Pulmonary Embolism / etiology
  • Pulmonary Embolism / prevention & control
  • Quality Improvement
  • Retrospective Studies
  • Risk Adjustment
  • Risk Factors
  • Venous Thrombosis / epidemiology
  • Venous Thrombosis / etiology*
  • Venous Thrombosis / prevention & control

Substances

  • Fibrinolytic Agents