Production of T suppressor factor specific for the hapten picryl chloride requires both T suppressor cells and an antigen-specific, genetically restricted second signal

Ann Inst Pasteur Immunol. 1987 Nov-Dec;138(6):815-27. doi: 10.1016/s0769-2625(87)80002-8.

Abstract

We investigated the requirement for activation of T suppressor cells specific for the hapten picryl chloride and the release of hapten-specific T suppressor factor. Using an in vivo experimental system, we report that activation of T suppressor cells and the consequent release of T suppressor factor required two signals: one was provided by primed T suppressor cells, i.e. spleen cells from mice injected with the tolerogen picrylsulphonic acid, and the other was provided by the specific antigen in the context of H-2 gene products. Mechanisms by which the interaction between these two signals led to activation of T suppressor cells and the production of T suppressor factor, as well as a comparison with other antigen-specific suppressor systems, are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Disulfides / immunology
  • Epitopes / immunology
  • Female
  • H-2 Antigens / immunology*
  • Haptens / immunology
  • Male
  • Mice
  • Mice, Inbred Strains
  • Oxidation-Reduction
  • Picryl Chloride / immunology*
  • Spleen / immunology
  • Spleen / metabolism
  • Suppressor Factors, Immunologic / biosynthesis*
  • Suppressor Factors, Immunologic / genetics
  • T-Lymphocytes, Regulatory / immunology*

Substances

  • Disulfides
  • Epitopes
  • H-2 Antigens
  • Haptens
  • Suppressor Factors, Immunologic
  • Picryl Chloride