Invasive fungal diseases during first induction chemotherapy affect complete remission achievement and long-term survival of patients with acute myeloid leukemia

Leuk Res. 2014 Apr;38(4):469-74. doi: 10.1016/j.leukres.2014.01.007. Epub 2014 Jan 20.

Abstract

We retrospectively evaluated, in a logistic-regression-model, the role of proven/probable invasive fungal diseases (PP-IFD), occurring during first induction chemotherapy, on the achievement of complete remission (CR) and overall survival (OS) in 198 acute myeloid leukemia (AML) patients. A PP-IFD was documented in 34 (17.2%) patients. Younger age, good performance status at AML diagnosis and no development of a PP-IFD (OR 4.09, 95% CI 1.71-9.81, p<0.0001) were independent factors associated to CR achievement. Younger age, good performance status, favorable genetic risk and no development of PP-IFD (HR 1.86, 95% CI 1.20-2.88, p=0.005) were independent factors associated to OS at 3 years.

Keywords: Acute myeloid leukemia; Aspergillosis; Complete remission; Invasive fungal disease; Survival.

MeSH terms

  • Adult
  • Aged
  • Female
  • Humans
  • Incidence
  • Induction Chemotherapy / adverse effects*
  • Leukemia, Myeloid, Acute / drug therapy*
  • Leukemia, Myeloid, Acute / mortality*
  • Male
  • Middle Aged
  • Mycoses / etiology*
  • Neoadjuvant Therapy
  • Remission Induction
  • Retrospective Studies
  • Survival Analysis
  • Young Adult