Abstract
This study evaluates the antimicrobial susceptibilities and serotype distributions of invasive Streptococcus pneumoniae (SP) isolates identified in a Turkish hospital before the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7). The susceptibilities of all isolates were determined by evaluating six antibiotics: penicillin (PEN), ceftriaxone (CRO), levofloxacin (LEV), erythromycin (ERY), clindamycin (CD), and vancomycin (VAN). Serotyping and amplification of macrolide resistance genes were performed. Sixteen (50%) and four (2%) isolates were resistant to PEN and LEV, respectively. No isolates demonstrated VAN resistance. Intermediate resistance to CRO was found in 4% of all invasive isolates. Twenty-three (12.6%) isolates were resistant to ERY. Four (2%) invasive SP isolates demonstrated multidrug resistance. Serogroups 3, 5, 6, 8, 9, and 23 were the most common in both age groups. The potential coverage rates of PCV7 and PCV13 were 44.1 and 66.1% in children and 39.8 and 71.5% in adults, respectively. Continuous surveillance of antimicrobial resistance is required.
Keywords:
Antimicrobial resistance,; PCR,; PCV13,; PCV7,; Serotype,; Streptococcus pneumoniae.
Publication types
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Blood / microbiology
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Cerebrospinal Fluid / microbiology
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Child
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Disk Diffusion Antimicrobial Tests
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Drug Resistance, Bacterial*
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Drug Resistance, Multiple, Bacterial
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Genes, Bacterial
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Heptavalent Pneumococcal Conjugate Vaccine / immunology
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Heptavalent Pneumococcal Conjugate Vaccine / therapeutic use
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Hospitals, Pediatric
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Hospitals, University
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Humans
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Macrolides / pharmacology
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Macrolides / therapeutic use*
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Nucleic Acid Amplification Techniques
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Pneumococcal Infections / drug therapy*
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Pneumococcal Infections / prevention & control
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Pneumococcal Vaccines / immunology
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Pneumococcal Vaccines / therapeutic use
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Product Surveillance, Postmarketing
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Serotyping
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Streptococcus pneumoniae / classification
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Streptococcus pneumoniae / drug effects*
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Streptococcus pneumoniae / immunology
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Streptococcus pneumoniae / isolation & purification
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Turkey
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Vaccines, Conjugate / immunology
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Vaccines, Conjugate / therapeutic use
Substances
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13-valent pneumococcal vaccine
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Anti-Bacterial Agents
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Heptavalent Pneumococcal Conjugate Vaccine
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Macrolides
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Pneumococcal Vaccines
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Vaccines, Conjugate