In situ proteome profiling of C75, a covalent bioactive compound with potential anticancer activities

Xiamin Cheng; Lin Li; Mahesh Uttamchandani; Shao Q Yao

doi:10.1021/ol500206w

In situ proteome profiling of C75, a covalent bioactive compound with potential anticancer activities

Org Lett. 2014 Mar 7;16(5):1414-7. doi: 10.1021/ol500206w. Epub 2014 Feb 19.

Authors

Xiamin Cheng¹, Lin Li, Mahesh Uttamchandani, Shao Q Yao

Affiliation

¹ Department of Chemistry, National University of Singapore , 3 Science Drive 3, Singapore, 117543.

PMID: 24552542
DOI: 10.1021/ol500206w

Abstract

A library of cell-permeable, minimally tagged C75 analogues was synthesized and used to uncover biological targets in human liver cancer cells. Known targets of C75, namely FASN and CPT1A, together with other unknown targets, including PDIA3, TFRC, and GAPDH, were thus identified.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

4-Butyrolactone / analogs & derivatives*
4-Butyrolactone / chemistry
4-Butyrolactone / pharmacology
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Apoptosis / drug effects
Humans
Liver Neoplasms
Molecular Structure
Small Molecule Libraries

Substances

Antineoplastic Agents
Small Molecule Libraries
4-Butyrolactone