Enantioselective formal α-allylation of nitroalkanes through a chiral iminophosphorane-catalyzed Michael reaction-Julia-Kocienski olefination sequence

Chem Commun (Camb). 2014 Apr 4;50(26):3491-3. doi: 10.1039/c3cc49477b. Epub 2014 Feb 20.

Abstract

A two-step sequence for the asymmetric formal α-allylation of nitroalkanes is disclosed. This new methodology relies on the development of a highly diastereo- and enantioselective conjugate addition of nitroalkanes to vinylic 2-phenyl-1H-tetrazol-5-ylsulfones using chiral triaminoiminophosphorane as a requisite base catalyst and subsequent Julia-Kocienski olefination under kinetic conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkanes / chemistry*
  • Catalysis
  • Imines / chemistry*
  • Phosphoranes / chemistry*
  • Stereoisomerism

Substances

  • Alkanes
  • Imines
  • Phosphoranes