Abstract
The erm(41) gene causes inducible macrolide resistance in Mycobacterium abscessus but not Mycobacterium chelonae. erm(41) sequencing of 285 M. abscessus and 45 M. chelonae isolates was compared to 14-day susceptibility; agreement percentages were 98.9% and 100%, respectively. Extended incubation may not be necessary for M. chelonae, and the erm(41) genotype is a useful adjunct for M. abscessus.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Clarithromycin / pharmacology
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DNA, Bacterial / genetics
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Drug Resistance, Bacterial / genetics
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Genes, Bacterial / genetics*
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Macrolides / pharmacology*
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Microbial Sensitivity Tests / methods
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Mycobacterium / drug effects
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Mycobacterium / genetics*
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Mycobacterium Infections, Nontuberculous / diagnosis*
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Mycobacterium Infections, Nontuberculous / drug therapy
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Mycobacterium Infections, Nontuberculous / microbiology*
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Mycobacterium chelonae / drug effects
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Mycobacterium chelonae / genetics*
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Polymerase Chain Reaction / methods
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Sequence Analysis, DNA / methods
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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Macrolides
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Clarithromycin