Azole-resistant Aspergillus fumigatus isolate with the TR34/L98H mutation in both a fungicide-sprayed field and the lung of a hematopoietic stem cell transplant recipient with invasive aspergillosis

J Clin Microbiol. 2014 May;52(5):1724-6. doi: 10.1128/JCM.03182-13. Epub 2014 Feb 19.

Abstract

A French farmer developed invasive aspergillosis with azole-resistant Aspergillus fumigatus with the TR34/L98H mutation following a hematopoietic stem cell transplantation. He had worked in fungicide-sprayed fields where a non-genetically related A. fumigatus TR34/L98H isolate was collected. If azole resistance detection increases, voriconazole as first-line therapy might be questioned in agricultural areas.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / pharmacology
  • Aspergillosis / drug therapy
  • Aspergillosis / microbiology*
  • Aspergillus fumigatus / drug effects
  • Aspergillus fumigatus / genetics*
  • Aspergillus fumigatus / isolation & purification
  • Azoles / pharmacology*
  • Drug Resistance, Multiple, Fungal / genetics
  • Fungal Proteins / genetics
  • Fungicides, Industrial / pharmacology*
  • Hematopoietic Stem Cell Transplantation / methods
  • Hematopoietic Stem Cells / drug effects
  • Hematopoietic Stem Cells / microbiology*
  • Humans
  • Lung / drug effects
  • Lung / microbiology*
  • Male
  • Middle Aged
  • Mutation / genetics*
  • Transplant Recipients

Substances

  • Antifungal Agents
  • Azoles
  • Fungal Proteins
  • Fungicides, Industrial