Orbital extra-medullary granulocytic sarcoma: clinicopathologic correlation with immunohistochemical features

Surv Ophthalmol. 2014 Mar-Apr;59(2):232-5. doi: 10.1016/j.survophthal.2013.06.004. Epub 2013 Oct 25.

Abstract

Orbital granulocytic sarcoma (chloroma), a rare tumor of immature myeloid cells, has nonspecific clinical and radiological features that make it a diagnostic challenge. Light microscopy and confirmation by immunostaining aid in the diagnosis. Knowledge of this entity is important because early diagnosis and prompt treatment are associated with better prognosis. We report a series of 31 biopsy-proven orbital granulocytic sarcomas with their immunohistochemical features and review the literature.

Keywords: chloroma; extramedullary; granulocytic sarcoma; leukemia; orbit.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Biomarkers, Tumor / metabolism
  • Child
  • Child, Preschool
  • Early Diagnosis
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Orbital Neoplasms* / metabolism
  • Orbital Neoplasms* / pathology
  • Sarcoma, Myeloid* / metabolism
  • Sarcoma, Myeloid* / pathology
  • Young Adult

Substances

  • Biomarkers, Tumor