Akt-ivation of RNA splicing

Gina Lee; John Blenis

doi:10.1016/j.molcel.2014.02.010

Akt-ivation of RNA splicing

Mol Cell. 2014 Feb 20;53(4):519-20. doi: 10.1016/j.molcel.2014.02.010.

Authors

Gina Lee¹, John Blenis²

Affiliations

¹ Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
² Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: [email protected].

PMID: 24560271
DOI: 10.1016/j.molcel.2014.02.010

Abstract

Cells must tightly control alternative splicing of RNA to maintain homeostasis; in this issue of Molecular Cell, Sanidas et al. (2014) provide new insights into the regulation of RNA splicing by Akt isoforms through phosphorylation of histone modification machinery.

Publication types

Comment

MeSH terms

Alternative Splicing*
Animals
Gene Expression Regulation, Neoplastic*
Humans
Lung Neoplasms / metabolism*
Proteins / metabolism*
Proto-Oncogene Proteins c-akt / metabolism*
RNA-Binding Proteins
Transcription Factors

Substances

Iws1 protein, human
Proteins
RNA-Binding Proteins
Transcription Factors
AKT1 protein, human
AKT3 protein, human
Proto-Oncogene Proteins c-akt