[Lymphatic extension and lymphangiogenesis in non-small cell lung cancer]

Rev Pneumol Clin. 2014 Feb-Apr;70(1-2):26-31. doi: 10.1016/j.pneumo.2013.09.008. Epub 2014 Feb 22.
[Article in French]

Abstract

Lymph node metastasis is a major adverse prognostic factor of malignant tumors, including non-small cell lung carcinoma (NSCLC). However the characterization of tumor associated lymphatic vessels and lymphangiogenic mediators in NSCLC are recent and their prognostic role is debated. Lymphatic vascular invasion (LVI) appears like a robust adverse prognostic factor when reported in NSCLC. This parameter should be better standardized and could be of use in adjuvant therapy indications. Moreover, anti-lymphangiogenesis therapies are currently under investigation and may become part of the anti-cancer strategy.

Keywords: Cancer du poumon; Lung cancer; Lymph nodes; Lymphangiogenesis; Lymphangiogenèse; Metastases; Métastases; Nœuds lymphatiques.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / pathology*
  • Carcinoma, Non-Small-Cell Lung / secondary*
  • Humans
  • Lung Neoplasms / pathology*
  • Lymphangiogenesis*
  • Lymphatic Metastasis
  • Lymphatic Vessels / pathology