Re-examining class-I presentation and the DRiP hypothesis

Trends Immunol. 2014 Apr;35(4):144-52. doi: 10.1016/j.it.2014.01.002. Epub 2014 Feb 21.

Abstract

MHC class I molecules present peptides derived from intracellular proteins, enabling immune surveillance by CD8(+) T cells and the elimination of virus-infected and cancerous cells. It has been argued that the dominant source of MHC class I-presented peptides is through proteasomal degradation of newly synthesized defective proteins, termed defective ribosomal products (DRiPs). Here, we critically examine the DRiP hypothesis and discuss recent studies indicating that antigenic peptides are generated from the entire proteome and not just from failures in protein synthesis or folding.

Keywords: MHC class I; antigen presentation; defective ribosomal product; proteasome.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology*
  • CD8-Positive T-Lymphocytes / immunology
  • Histocompatibility Antigens Class I / immunology*
  • Humans
  • Immunologic Surveillance / immunology*
  • Peptides / immunology
  • Proteome / immunology
  • Ribosomes / immunology

Substances

  • Histocompatibility Antigens Class I
  • Peptides
  • Proteome