Successful treatment of an infant infected with refractory C. parapsilosis with caspofungin

J Trop Pediatr. 2014 Aug;60(4):329-30. doi: 10.1093/tropej/fmu014. Epub 2014 Feb 24.

Abstract

Neonatal Candida infections are the leading cause of invasive fungal infections that might cause severe morbidity or mortality in a large majority of those affected. Although Candida albicans has been the most common species, Candida parapsilosis is increasingly being recognized as an important cause of invasive candidiasis in neonates. Among the Candida species, C. parapsilosis has been commonly isolated and shown to be less susceptible in vitro to echinocandins than other Candida species. We report an infant who had refractory C. parapsilosis septicemia cured with caspofungin.

Keywords: Candida parapsilosis; caspofungin; infant.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / administration & dosage
  • Antifungal Agents / therapeutic use*
  • Candida / classification
  • Candida / drug effects*
  • Candida / isolation & purification
  • Candidiasis / congenital
  • Candidiasis / drug therapy*
  • Candidiasis / microbiology
  • Caspofungin
  • Drug Resistance, Fungal*
  • Echinocandins / administration & dosage
  • Echinocandins / therapeutic use*
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / drug therapy*
  • Infant, Premature, Diseases / microbiology
  • Lipopeptides
  • Microbial Sensitivity Tests
  • Treatment Outcome

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Caspofungin