Mycobacterium szulgai chronic multifocal osteomyelitis in an adolescent with inherited STAT1 deficiency

Pediatr Infect Dis J. 2013 Dec;32(12):1345-7. doi: 10.1097/01.inf.0000437067.43859.4c.

Abstract

We report a 17-year-old patient with inherited STAT1 deficiency, who was diagnosed with Mycobacterium szulgai chronic multifocal osteomyelitis and responded well to the therapy with ethambutol, rifampicin and azithromycin. Seven other reported cases of M. szulgai osteomyelitis are reviewed. This is the first description of M. szulgai osteomyelitis in an adolescent with a primary immunodeficiency.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antibiotics, Antitubercular / pharmacology
  • Antibiotics, Antitubercular / therapeutic use
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Mycobacterium Infections, Nontuberculous / genetics
  • Mycobacterium Infections, Nontuberculous / metabolism*
  • Mycobacterium Infections, Nontuberculous / microbiology
  • Nontuberculous Mycobacteria / drug effects
  • Nontuberculous Mycobacteria / isolation & purification*
  • Osteomyelitis / genetics
  • Osteomyelitis / metabolism*
  • Osteomyelitis / microbiology*
  • STAT1 Transcription Factor / deficiency*
  • STAT1 Transcription Factor / genetics

Substances

  • Antibiotics, Antitubercular
  • STAT1 Transcription Factor
  • STAT1 protein, human

Supplementary concepts

  • Chronic recurrent multifocal osteomyelitis