Abstract
Here, we report the results of a late boost and three additional series of simian immunodeficiency virus (SIV) challenges in seven DNA/modified vaccinia virus Ankara (MVA)-vaccinated rhesus macaques who resisted a first series of rectal challenges. During 29 additional challenges delivered over 2.3 years, all animals became infected. However, 13 blips of virus in six macaques and anamnestic Env-specific rectal IgA responses in three of the six suggested that local control of infections was occurring during the serial challenge.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Drug Carriers
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Immunity, Mucosal*
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Macaca mulatta
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Rectum / immunology*
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SAIDS Vaccines / administration & dosage
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SAIDS Vaccines / immunology*
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Simian Acquired Immunodeficiency Syndrome / prevention & control*
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Simian Immunodeficiency Virus / immunology*
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Vaccines, DNA / administration & dosage
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Vaccines, DNA / immunology*
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Vaccines, Synthetic / administration & dosage
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Vaccines, Synthetic / immunology
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Vaccinia virus / genetics
Substances
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Drug Carriers
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SAIDS Vaccines
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Vaccines, DNA
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Vaccines, Synthetic