Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor

Blood. 2014 Feb 27;123(9):1422-4. doi: 10.1182/blood-2013-11-540641.
No abstract available

Publication types

  • Letter

MeSH terms

  • B-Lymphocytes / immunology
  • B-Lymphocytes / transplantation
  • Cells, Cultured
  • Genetic Therapy*
  • Genetic Vectors*
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells
  • Humans
  • Immunotherapy, Active*
  • Lentivirus*
  • Lymphocyte Activation
  • Membrane Glycoproteins / genetics*
  • Receptors, LDL / metabolism*
  • T-Lymphocytes / immunology
  • T-Lymphocytes / transplantation
  • Transduction, Genetic*
  • Treatment Failure
  • Viral Envelope Proteins / genetics*
  • Virus Internalization

Substances

  • G protein, vesicular stomatitis virus
  • Membrane Glycoproteins
  • Receptors, LDL
  • Viral Envelope Proteins