Interphase chromatin LINEd with RNA

Ryu-Suke Nozawa; Nick Gilbert

doi:10.1016/j.cell.2014.02.005

Interphase chromatin LINEd with RNA

Cell. 2014 Feb 27;156(5):864-5. doi: 10.1016/j.cell.2014.02.005.

Authors

Ryu-Suke Nozawa¹, Nick Gilbert²

Affiliations

¹ MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.
² MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK. Electronic address: [email protected].

PMID: 24581484
DOI: 10.1016/j.cell.2014.02.005

Abstract

RNA has been proposed to be a component of an underlying nuclear matrix. Hall et al. show that noncoding, repetitive RNAs, some derived from LINE1 elements, stably associate with interphase chromosomes and copurify with nuclear scaffold, indicating that RNAs might impact interphase chromosome architecture.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Chromosomes, Mammalian / chemistry*
Euchromatin / chemistry*
Humans
Interphase*
RNA, Untranslated / analysis*

Substances

Euchromatin
RNA, Untranslated

Grants and funding

MR/J00913X/1/Medical Research Council/United Kingdom