Abstract
Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity in Bangladesh. We find that human APOBEC3G can induce genetic changes that may prevent SFV replication in infected humans in vivo.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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APOBEC Deaminases
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APOBEC-3G Deaminase
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Animals
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Bangladesh
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Bayes Theorem
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Codon, Terminator
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Computational Biology
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Cytidine Deaminase / genetics
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Cytosine Deaminase / genetics*
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Host-Pathogen Interactions / genetics
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Humans
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Macaca / genetics
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Macaca / virology
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Models, Genetic
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Mutation*
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RNA, Viral / genetics
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Retroviridae Infections / genetics*
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Retroviridae Infections / transmission*
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Simian foamy virus / genetics*
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Simian foamy virus / pathogenicity
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Simian foamy virus / physiology
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Species Specificity
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Virus Replication
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Zoonoses / genetics*
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Zoonoses / transmission*
Substances
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Codon, Terminator
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RNA, Viral
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Cytosine Deaminase
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APOBEC Deaminases
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APOBEC-3G Deaminase
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APOBEC3 proteins, human
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APOBEC3G protein, human
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Cytidine Deaminase